Kei te taha mua o te rangahau pūtaiao te Imperial College London (ICL), ā, mā roto i te Tari Pūtaiao Ārai Mate me te Mumura me te Tari Pūtaiao Roro, ka horapa āna rangahau mai i te mate rumatiki me te mate toto ki te mate wareware, te mate a Parkinson me te mate pukupuku roro. Ko te whakahaere i ēnei rangahau kanorau me whai whare hou, inā koa mō te rokiroki i ngā tauira koiora nui. I kite a Neil Galloway Phillipps, te Kaiwhakahaere Taiwhanga Matua mō ngā tari e rua, i te hiahia mō tētahi otinga rokiroki cryogenic whai hua me te pumau.
Ngā Hiahia o te ICL
1.He pūnaha rokiroki hauota wai whakapūmau, kaha teitei
2.Te whakaiti i te whakamahinga hauota me ngā utu whakahaere
3.Te haumarutanga tauira me te hanganga ture kua whakapaitia
4.He urunga haumaru ake, he urunga whai hua ake hoki mō ngā kairangahau
5.He otinga pumau hei tautoko i ngā kaupapa matomato
Ngā wero
I mua, i whakawhirinaki te Tari Ārai Mate o ICL ki te 13 hauota wai pūmau motuhake (LN2) ngā tāke hei penapena i ngā tauira whakamātautau haumanu, ngā pūtau amiorangi me ngā ahurea pūtau tuatahi. He roa te wā e pau ana ki te tiaki i tēnei pūnaha pakaru, me te hiahia kia aroturukitia tonutia me te whakakī anō.
"He roa te wā i pau i te whakakī i ngā tāke 13, ā, kua uaua haere te aroturuki i ngā mea katoa," te whakamārama a Neil. "He wero whakahaere, ā, i hiahiatia he huarahi whai hua ake hei whakahaere i tā mātou rokiroki."
Ko te utu mō te tiaki i ngā tāke maha tētahi atu āwangawanga.2he nui te whakamahinga, ā, i piki ake ai ngā whakapaunga whakahaere. I taua wā anō, ko te pānga ki te taiao o ngā tukunga hauota auau he rerekē ki te whakapau kaha a te taiwhanga ki te oranga tonutanga. "Kei te mahi mātou ki ngā tohu oranga tonutanga maha, ā, i mōhio mātou he nui te rerekētanga ka puta mai i te whakaiti i tā mātou whakamahinga hauota," te kī a Neil.
Ko te haumarutanga me te tutuki i ngā whakaritenga he mea nui anō hoki. Nā te maha o ngā tāke e horapa ana puta noa i ngā rohe rerekē, he uaua te aroturuki i te urunga me te pupuri i ngā tuhinga hou. "He mea nui kia mōhio tātou ko wai kei te uru atu ki ngā tauira, ā, kia tika te penapena i ngā mea katoa kia rite ki ngā ture a te Mana Tio Tangata (HTA)," te tāpiri a Neil. "Kāore i ngāwari te pūnaha tawhito."
Te otinga
Kua whai a ICL i te whānuitanga o ngā taputapu mai i Haier Biomedical – tae atu ki te rokiroki makariri, ngā kāpata haumaru koiora, CO2ngā incubator me ngā centrifuge – te whakawhanake i te whakawhirinaki ki ngā otinga a te kamupene.
Nō reira, i whakapā atu a Neil mā ki a Haier Biomedical hei āwhina i te whakatika i ēnei wero hou, mā te tāuta i te CryoBio 43 LN nui-kaha.2biobank ki te whakakotahi i ngā tāke pūmau 13 katoa ki roto i tētahi pūnaha whai hua nui. He maeneene te whakawhiti, me te tīma a Haier e whakahaere ana i te tāutanga me te whakangungu i ngā kaimahi taiwhanga. I whakauruhia te pūnaha hou ki roto i te LN o nāianei2whare me ngā whakarerekētanga iti noa iho. Nā te pūnaha hou kua whakatinanahia, kua tino whai hua ake te rokiroki me te whakahaere tauira. "Ko tētahi o ngā painga ohorere ko te nui o te wāhi i riro mai i a mātou," te kī a Neil. "Nā te tango atu i aua tāke tawhito katoa, he nui ake te wāhi i roto i te taiwhanga mō ētahi atu taputapu."
Nā te huri ki te rokiroki āhua-kohu kua whakarei ake i te haumaru me te ngāwari o te whakamahi. "I mua, i ia wā ka tangohia e mātou he whata mai i te tāke āhua-wai, ka maturuturu iho te hauota, he mea e āwangawanga tonu ana mō te haumaru. Ināianei, me te rokiroki āhua-kohu, he ma ake, he haumaru ake hoki te whakahaere i ngā tauira. Kua whakapakari ake hoki te pūnaha urunga koiora i te haumarutanga me te tutuki i ngā whakaritenga nā te mea ka taea e mātou te whai i te hunga e uru atu ana ki te pūnaha me te wā."
I kitea e Neil rātou ko tana tīma he māmā noa te whakamahi i te pūnaha, nā te kaupapa whakangungu a Haier i taea ai e rātou te whakauru wawe i ngā kaiwhakamahi mutunga.
He āhuatanga ohorere engari he mea whakamīharo ko ngā kaupae hurihuri aunoa, e māmā ake ai te uru atu ki te tāke. "I ngā tāke o mua, he maha ngā wā i tika ai kia hiki ake ngā taonga e ngā kairangahau i te toronga katoa. Ahakoa he teitei ake te tāke hou, ka taea te whakatū i ngā kaupae mā te pēhi i te pātene, ā, he māmā ake te whakahaere i te tāpiri, te tango rānei i ngā tauira," te kōrero a Neil.
Te tiaki i ngā tauira whai hua
He mea tino nui ngā tauira e rongoatia ana i roto i te whare whakapūkara a ICL mō ngā rangahau tonu. "Ko ētahi o ngā tauira e rongoatia ana e mātou kāore e taea te whakakapi," te kī a Neil.
"Kei te kōrero tātou mō ngā whakaritenga pūtau toto mā mai i ngā mate onge, ngā tauira whakamātautau haumanu, me ētahi atu rauemi e tika ana mō te rangahau. Kāore ēnei tauira e whakamahia ana i roto i te taiwhanga anake; ka tohaina ki ngā hoa mahi huri noa i te ao, ā, he mea tino nui te pono o ēnei. Ko te oranga tonutanga o ēnei pūtau te mea nui. Ki te kore e rongoatia tika, ka taea te whakararu i te rangahau e tautokona ana e rātou. Koia mātou e hiahia ana ki tētahi rokiroki makariri tino pono ka taea e mātou te whakawhirinaki. Mā te pūnaha Haier, ka tino marino tō mātou hinengaro. Ka taea e mātou te tirotiro i te kōtaha pāmahana i ngā wā katoa, ā, ki te tirotirohia mātou, ka taea e mātou te whakaatu maia kua rongoatia tika ngā mea katoa."
Te whakapai ake i te pumau me te whai huatanga o te utu
Nā te whakaurunga mai o te pēke koiora hou kua tino whakaitihia te whakamahinga hauota wai a te taiwhanga, kia tekau ngā whakarea. "E 125 rita te nui o te wai i roto i ia tāke tawhito, nō reira kua nui te rerekētanga i puta mai i te whakakotahitanga o aua tāke," te whakamārama a Neil. "Kei te whakamahia e mātou he wāhanga iti noa iho o te hauota i whakamahia e mātou i mua, ā, he wikitoria nui tēnā i te taha pūtea me te taha taiao."
Nā te iti o ngā tukunga hauota e hiahiatia ana, kua whakaitihia ngā tukunga waro, hei tautoko i ngā whāinga pumau a te taiwhanga. "Ehara i te mea ko te hauota tonu anake te mea nui," te tāpiri a Neil. "Mā te iti o ngā tukunga ka iti ake ngā taraka i runga i te rori, ā, ka iti ake te pūngao e whakamahia ana hei whakaputa i te hauota i te tuatahi." He tino hira ēnei whakapainga, ā, i whakawhiwhia a Imperial ki ngā tohu pumau mai i a LEAF me My Green Lab hei whakamihi i āna mahi.
Whakamutunga
Kua hurihia e te pēke koiora kiriuhi a Haier Biomedical ngā āheinga rokiroki a ICL, kua whakapai ake i te whai huatanga, te haumaru me te pumau, me te whakaiti nui i ngā utu. Nā te pai ake o te tutuki i ngā whakaritenga, te haumaru tauira kua whakarei ake, me te whakaiti i te pānga ki te taiao, he angitu nui te whakahoutanga.
Ngā Hua o te Kaupapa
1.LN2te whakaiti i te whakamahinga mā te 90%, te tapahi i ngā utu me ngā tukunga
2.He whai hua ake te aroturukitanga tauira me te tutuki i ngā whakaritenga HTA
3.Te rokiroki haumaru ake i te wā-kohu mō ngā kairangahau
4.Te whakanui ake i te kaha rokiroki i roto i te pūnaha kotahi
5.Te whakamihi mā roto i ngā tohu oranga tonutanga
Wā tuku: Pipiri-23-2025
